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We also showed that G47∆ was able to induce the regression of tumor xenografts in BALB/c nude mice and demonstrated the ability of G47∆ to synergize with paclitaxel by killing both NCSCs and CSCs, suggesting that o HSV may be an effective treatment modality for patients with breast cancer.
The cancer stem cell (CSC) theory proposes that tumor cells are composed of a heterotypic population of cells and the CSCs, which comprise a small percentage of the total tumor, remain at the top of the cellular hierarchy with unlimited proliferation potential and pluripotency (1,2).
Every year, APO's iconic Oblation Run, which features frat men running naked around the UP Diliman campus, is dedicated to a worthy cause.
This year's run will be a protest against Marcos' interment at the heroes' cemetery.
Mikhail Red’s “Birdshot,” which is the fest’s Centerpiece Gala, is included in the main competition section, vying for the top prize.
Also to be showcased in the fest are Jet Leyco’s “Town in a Lake (Matangtubig)” and Avid Liongoren’s “Saving Sally,” as part of the fest’s continuing “efforts to champion films from Southeast Asia …
Our findings provide a rationale for the clinical evaluation of CFI-400945 in patients with solid tumors, in particular those deficient in PTEN.
Breast cancer is a complex and heterogeneous disease.
Gene expression profiling has contributed significantly to our understanding of this heterogeneity at a molecular level, refining taxonomy based on simple measures such as histological type, tumour grade, lymph node status and the presence of predictive markers like oestrogen receptor and human epidermal growth factor receptor 2 (HER2) to a more sophisticated classification comprising luminal A, luminal B, basal-like, HER2-positive and normal subgroups.
Despite these early accomplishments, relatively few breast cancer cell lines have been established in the more recent past, mainly because of difficulties in culturing homogeneous populations without significant stromal contamination and, at least in the United Kingdom, partly due to rigorous ethical regulations surrounding obtaining human tissue for research [Long before the advent of modern molecular profiling techniques, histopathologists recognised that breast cancer was heterogeneous through morphological observations.
Classification was based on the following measures: histological type, tumour grade, lymph node status and the presence of predictive markers such as ER and, more recently, human epidermal growth factor receptor 2 (HER2).